Early onset of diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Early Diabetic Nephropathy
OBJECTIVE Diabetic nephropathy (DN) is a major cause of mortality in type 1 diabetes. Reduced insulin sensitivity is a well-documented component of type 1 diabetes. We hypothesized that baseline insulin sensitivity would predict development of DN over 6 years. RESEARCH DESIGN AND METHODS We assessed the relationship between insulin sensitivity at baseline and development of early phenotypes o...
متن کاملEarly-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy
The transgenic E1-DN mice express a kinase-negative epidermal growth factor receptor in their pancreatic islets and are diabetic from two weeks of age due to impaired postnatal growth of β-cell mass. Here, we characterize the development of hyperglycaemia-induced renal injury in the E1-DN mice. Homozygous mice showed increased albumin excretion rate (AER) at the age of 10 weeks; the albuminuria...
متن کاملEarly signs of diabetic nephropathy in childhood
337 ISSN 1758-1907 10.2217/DMT.12.37 © 2012 Future Medicine Ltd Diabetes Manage. (2012) 2(4), 337–353 Summary Diabetes represents the single largest cause of end-stage kidney failure in adults. Although diabetic nephropathy is an uncommon cause of kidney failure during childhood, there is clear evidence that the underlying events increase to progressive kidney injury begin during childhood and ...
متن کاملDiabetic nephropathy. Prevention and early referral.
OBJECTIVE To review the clinical and pathophysiologic features of diabetic nephropathy and to examine evidence supporting primary, secondary, and tertiary treatment strategies. QUALITY OF EVIDENCE The medical literature provides both level 1 and level 2 evidence on treatment of diabetic nephropathy, including randomized controlled trials, well-designed clinical trials without randomization, c...
متن کاملEarly-start dialysis in diabetic nephropathy.
Department of Medicine, Dunedin School of Medicine, University of Otago Medical School, Dunedin, New Zealand T he point at which dialysis is initiated is still largely an empirical decision that is influenced by a number of variables, many of which are not actually linked to the individual's end-stage renal failure but rather to economic and social factors (1). The traditional approach has been...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1997
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.77.6.524